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Abstract Recently, there is an urgent need for new drugs due to the emergence of drug resistant pathogenic microorganisms and new infectious diseases. Keywords: actinobacteria, cave, karst, bioactive compounds, diversity, antimicrobial, anticancer, natural products. Introduction Caves are generally regarded as any natural underground chamber that is large enough for human entrance.
Selective Isolation of Cave Actinobacteria In the past decade, there are many reports on the discovery of novel actinobacteria in cave habitats. Novel Actinobacterial Taxa Several novel actinobacterial taxa isolated from caves and cave related habitats during the period of 20 years from to were summarized in Table 1. Table 1 Novel actinobacterial taxa isolated from cave and related habitats between and Open in a separate window. Bioactive Compounds From Cave Actinobacteria Caves are extreme habitats with low nutrient, temperature and light intensity but have high humidity Schabereiter-Gurtner et al.
Table 2 Bioactive metabolites from cave actinobacteria. Bioactivity of Uncharacterized Compounds Several cave actinobacteria have been screened for their biological activity such as antibacterial, anticancer and antifungal. Conclusion and Future Perspectives Emerging and re-emerging infectious diseases are threatening human society at an alarming rate. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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